Syntheses of 4′-Deoxykanamycin and 4′-Deoxykanamycin B
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چکیده
منابع مشابه
Practical syntheses of 4-fluoroprolines.
4-Fluoroprolines are among the most useful nonnatural amino acids in chemical biology. Here, practical routes are reported for the synthesis of the 2S,4R, 2S,4S, and 2R,4S diastereomers of 4-fluoroproline. Each route starts with (2S,4R)-4-hydroxyproline, which is a prevalent component of collagen and hence readily available, and uses a fluoride salt to install the fluoro group. Hence, the route...
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Reaction of thionyl chloride with 2-acetyl-1- benzenesulfonylpyrrole semicarbazone (6 c) gave 4 - (1- benzenesulfonyl-2 - pyrrolyl) - 1, 2, 3 -thiadiazole (lc). Selenium dioxide oxidation of 2-acetylpyrazine semicarbazone (10) in acetic acid afforded 4- (2-pyrazinyl) - 1, 2, 3- selenadiazole (4). Reaction of thionyl chloride with compound 10 gave 4- (2-pyrazinyl) - 1, 2, 3- thiadiazole (3)....
متن کاملSynthesis of 3'-deoxy-3'-fluorokanamycins A and B active against resistant bacteria.
Sir: Kanamycins are inactivated by enzymes of resistant bacteria phosphorylating or adenylylating the 3', 4' or 2"-hydroxyl groups' 21 , among which the 3'-hydroxyl group is most frequently modified. Syntheses of 3'-deoxykanamycin A3), 3',4'-dide-oxykanamycin B4) (dibekacine), and other deoxy derivatives of kanamycins and related aminogly-coside antibiotics were the major solution"" in order to...
متن کاملSYNTHESES, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF 2-ARYL-4- QUINOLINE- CARBOXAMIDE DERIVATIVES
Reaction of aryl methyl ketone with isatin in the presence of a base afforded 2- arylquinoline-4-carboxylic acid (3). Reaction of diazomethane with compound 3 yielded the ester 4. Compound 5 was prepared from the reaction of N, N'-dialkylethyl (or propyl) arnine with 4. Addition of hydrazine hydrate to compound 4a gave 2- (2- pyridyl) quinoline-4-carboxylic acid hydrazide (6). Reaction of l...
متن کاملSyntheses and Evaluation of the Analgesic Activity of Some 4-Acetyl- 4-phenylpiperidine and 4-Hydroxy-4-phenylpiperidine Derivatives
Z a fa r S aeed Saify3, K halid M oham m ed K hanb, Syed M oazzam H a id e r3, Z e e sh a n b, Syed T asad aq u e A li S hahb, M uham m ad S aeedc, M oham m ed Saleh S h ek h an id, and W olfgang V o e lte rc a Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi b International Center for Chemical Sciences, HEJ Research Institute of Chemistry, University of Karach...
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ژورنال
عنوان ژورنال: Bulletin of the Chemical Society of Japan
سال: 1977
ISSN: 0009-2673,1348-0634
DOI: 10.1246/bcsj.50.2362